Association of baseline and longitudinal changes in cardiometabolic health with risk of heart failure among adults with type 2 diabetes: an analysis from the Look AHEAD trial

Abstract Background Type 2 diabetes (T2D) is characterized by co-morbid cardiometabolic abnormalities and elevated heart failure (HF) risk. Purpose The purpose of this study was to evaluate the associations baseline longitudinal changes in health with risk HF among adults T2D. Methods Adults T2D enrolled Look AHEAD (Action for Health Diabetes) trial without prevalent were included. Adjusted Cox models used create a score incorporating target levels parameters weighted based on relative HF. baseline, 1- 4-year overall HF, preserved ejection fraction (HFpEF; EF≥50%), reduced EF (HFrEF; EF<50%) assessed using adjusted models. Results Of 5,080 participants included, there 257 incident events during 12.4-year follow-up. included 2-points each waist circumference, glomerular filtration rate, urine albumin-to-creatinine ratio 1-point blood pressure hemoglobin A1c at (Table 1). Higher significantly associated lower (adjusted hazard [aHR] per 1-unit higher score, 0.72 [95% CI, 0.66–0.79]) similar observed HFpEF HFrEF 2). Improvement over 4-years (aHR increase 4-years, 0.82 0.73–0.92] 0.80 0.70–0.91], respectively). Conclusions Among T2D, achieving more sustained improvements Funding Acknowledgement funding sources: Public grant(s) – National budget only. Main source(s): Institute Diabetes Digestive Kidney Diseases